Aceptabilidad a usar profilaxis pre-exposición para VIH en hombres gay y otros hombres que tienen sexo con hombres: indagación en LAMIS 2018 Chile / Acceptability of pre-exposure prophylaxis for HIV prevention among gay men and other men who have sex with men: analysis of LAMIS 2018-Chile

INTRODUCCIÓN: Chile enfrenta una reemergencia de la epidemia del VIH concentrada en hombres gay y otros HSH. La profilaxis pre exposición (PrEP) es una intervención biomédica que ha resultado ser efectiva en la prevención del VIH en el grupo de HSH. OBJETIVO: Estimar niveles de aceptabilidad del uso de PrEP en hombres gay y otros HSH participantes en estudio LAMIS 2018 - Chile, identificando características y factores asociados a la aceptabilidad del uso de PrEP. MATERIAL Y MÉTODOS: Estudio basado en datos de LAMIS-2018 Chile, encuesta transversal por internet dirigida a hombres gay, bisexual, trans y otros HSH. La submuestra de este estudio consiste en 3.976 participantes que se auto-reportaron ser VIH negativos o desconocer su estado serológico, quienes respondieron preguntas sociodemográficas, de comportamiento, sobre su aceptabilidad a usar PrEP y otros aspectos relacionados. Se realizó análisis bivariados y regresión logística multivariable para identificar los factores asociados a la aceptabilidad a usar PrEP. RESULTADOS Y DISCUSIÓN: Se identificó que 55,7% de la muestra reportó una alta aceptabilidad a usar la PrEP. La regresión logística multivariable mostró que tener relaciones sexuales sin condón (ORa = 1,67, IC 95% 1,42-1,97) y haber intentado usar PrEP (ORa = 1,99, IC 95% 1,41-1, 62) se asociaron positivamente a la aceptabilidad a usar PrEP mientras que tener una relación con pareja estable, se asoció negativamente. Se identificó una aceptabilidad a usar la PrEP relativamente alta en los participantes. No obstante, se hace necesario considerar intervenciones relacionada a aumentar el conocimiento y promover la demanda de la PrEP. Además, el presente estudio muestra la necesidad de considerar la participación de las organizaciones de la sociedad civil en su implementación, fenómenos emergentes y la pertinencia territorial.

BACKGROUND: Chile is facing a re-emergence of the HIV epidemic, concentrated among men who have sex with men (MSM). Pre-exposure prophylaxis (PrEP) is a biomedical intervention that effectively prevents HIV transmission among MSM. AIM: The study was designed to estimate acceptability of PrEP and identify factors associated with PrEP-related attitudes and behaviors among MSM using LAMIS 2018 - Chile study data. Methods: Data were taken from the LAMIS 2018 - Chile study, a cross-sectional study of gay, bisexual, transgender, and other MSM. Our subsample included 3976 participants with self-reported HIV-negative or unknown status who responded to sociodemographic questions and items related to PrEP. Bivariate analysis and multivariate logistic regression analysis were performed to identify factors associated with acceptability of PrEP. RESULTS AND DISCUSSION: A total of 55.7% of the sample reported high PrEP acceptability. Logistic regression indicated that engaging in sex without a condom (ORa = 1.67, IC 95% 1.42-1.97) and having previously used PrEP (ORa = 1.99, IC 95% 1.41-1.62) were associated with high acceptability to use PrEP, while having a stable partner was associated with low acceptability. The estimate of PrEP acceptability was relatively high among participants. However, interventions to increase awareness and promote demand for PrEP may be beneficial. Furthermore, this study demonstrates the need for non-governmental organizations to participate in such strategies and for measures that address regionally-relevant emerging phenomena.

[Acceptability of pre-exposure prophylaxis for HIV prevention among gay men and other men who have sex with men: analysis of LAMIS 2018-Chile]. / Aceptabilidad a usar profilaxis pre-exposición para VIH en hombres gay y otros hombres que tienen sexo con hombres: indagación en LAMIS 2018 Chile.

BACKGROUND: Chile is facing a re-emergence of the HIV epidemic, concentrated among men who have sex with men (MSM). Pre-exposure prophylaxis (PrEP) is a biomedical intervention that effectively prevents HIV transmission among MSM. AIM: The study was designed to estimate acceptability of PrEP and identify factors associated with PrEP-related attitudes and behaviors among MSM using LAMIS 2018 - Chile study data. METHODS: Data were taken from the LAMIS 2018 - Chile study, a cross-sectional study of gay, bisexual, transgender, and other MSM. Our subsample included 3976 participants with self-reported HIV-negative or unknown status who responded to sociodemographic questions and items related to PrEP. Bivariate analysis and multivariate logistic regression analysis were performed to identify factors associated with acceptability of PrEP. RESULTS AND DISCUSSION: A total of 55.7% of the sample reported high PrEP acceptability. Logistic regression indicated that engaging in sex without a condom (ORa = 1.67, IC 95% 1.42-1.97) and having previously used PrEP (ORa = 1.99, IC 95% 1.41-1.62) were associated with high acceptability to use PrEP, while having a stable partner was associated with low acceptability. The estimate of PrEP acceptability was relatively high among participants. However, interventions to increase awareness and promote demand for PrEP may be beneficial. Furthermore, this study demonstrates the need for non-governmental organizations to participate in such strategies and for measures that address regionally-relevant emerging phenomena.

Correlates of condomless anal intercourse among men who have sex with men in Santiago de Chile.

Men who have sex with men (MSM) are disproportionally affected by the HIV epidemic globally. In Chile, HIV prevalence among MSM is estimated at 20%, and condomless anal intercourse is the predominant mode of HIV transmission. This cross-sectional study aimed to estimate a broad array of characteristics in a sample of Chilean MSM including condomless anal intercourse (CLAI), as well as to explore possible associations between these characteristics and CLAI. MSM were recruited through respondent-driven sampling between June and October of 2016. A final sample size of 246 MSM was analyzed using CLAI as the outcome and sociodemographic, clinical and sexual risk behavior characteristics as exposure variables. Results show that close to half of the participants reported CLAI with casual sex partners during the last six months, and this outcome had an increased risk associated with use of drugs prior to sex and having had >5 sexual partners.

Menarquia temprana y su asociación con conductas de riesgo en adolescentes / Early menarche and its association with risk behaviors in adolescents

ANTECEDENTES: La pubertad no está necesariamente asociada a un desarrollo psicosocial equivalente. La falta de madurez y las características de la adolescencia podrían favorecer la aparición de conductas de riesgo. OBJETIVO: Determinar la asociación entre la edad de la menarquia y presencia de conductas de riesgo en adolescentes. MÉTODO: Diseño de corte transversal. La muestra incluyó adolescentes postmenárquicas. El instrumento fue una encuesta semiestructurada. Se realizó análisis descriptivo bivariado y multivariado. RESULTADOS: La muestra correspondió a 1844 adolescentes, la mediana de edad fue de 16 años y 12 años para la menarquia. El 57% provino de nivel socioeconómico medio, el 98% estaba escolarizada y 52% vivía con ambos padres. El 35,1% presentó menarquia temprana. El abuso sexual se presentó en 26,0% en el grupo de menarquia temprana y en 21,4% en el de menarquia no temprana. El inicio de actividad sexual antes de los 15 años se presentó en un 39,4% y en 22,3% de adolescentes con menarquia temprana y no temprana respectivamente (OR: 1,88; IC95%: 1,46-2,43), asociándose con disfuncionalidad familiar (OR: 2,08; IC95%: 1,45-2,99) y ausencia de los padres (OR: 1,74; IC95%: 1,09-2,76). La frecuencia de consumo de alcohol se asoció a disfuncionalidad familiar severa (OR: 2,00; IC95%: 1,34-3,00). CONCLUSIÓN: La menarquia temprana se asoció al inicio precoz de actividad sexual. Es importante promover comportamientos seguros desde edades tempranas y acompañar a las niñas en su proceso de maduración.

BACKGROUND: Puberty is not necessarily associated with an equivalent psychosocial development. The lack of maturity and characteristics of adolescence may promote the emergence of risk behaviors. OBJECTIVE: To determine the association between age at menarche and presence of risk behaviors in adolescents. METHOD: Cross-sectional design study. The sample included postmenarchal adolescents. The instrument was a semistructured survey. Bivariate and multivariate descriptive analysis. RESULTS: The sample consisted of 1844 adolescents, the median age was 16 years and 12 years for menarche. 57% came from middle socioeconomic level, 98% attended school and 52% lived with both parents. 35.1% had early menarche. Sexual abuse occurred in 26.0% in the group of early menarche and 21.4% for no early menarche. The onset of sexual activity before age 15 occurred in 39.4% and 22.3% of adolescents with early and no early menarche respectively (OR: 1.88; 95%CI: 1.46-2.43), associated with family dysfunction (OR: 2.08; 95%CI: 1.45-2.99) and absence of parents (OR: 1.74; 95%CI: 1.09-2.76). The frequency of alcohol consumption was associated with severe family dysfunction (OR: 2.00; 95%CI: 1.34-3.00). CONCLUSION: Early menarche was associated with early onset of sexual activity. It is important to promote safe behavior from an early age and escort girls in their maturation process.